Protein tyrosine phosphatase (PTP) family



Please choose the target genes to proceed




A. Class I Cys-Gased PTPs (99 Genes)


A. 1. Classical PTPs (38 Genes)
A. 1. 1. Transmembrane Classical PTPs (21 Genes)
1. PTPRA RPTP 20p13 NM_002836
2. PTPRB RPTP 12q15-q21 NM_002837
3. PTPRC CD45, LCA 1q31-q32
4. PTPRD RPTP 9p23-p24.3 NM_002839
5. PTPRE RPTP 10q26 NM_130435
6. PTPRF LAR 1p34 NM_003625
7. PTPRG RPTP 3p21-p14 NM_002841
8. PTPRH SAP1 19q13.4 NM_002842
9. PTPRJ DEP1, CD148, RPTP 11p11.2 NM_002843
10. PTPRK RPTP 6q22.2-23.1 NM_002844
11. PTPRM RPTP 18p11.2 NM_002845
12. PTPRN IA-2, Islet cell antigen 512 2q35-q36.1 NM_002846
13. PTPRN2 PTPRP, RPTP , IA-2, phogrin, 7q36 NM_130842
14. PTPRO GLEPP1/PTP-U2/PTPRO isoforms A/B/C 12p13.3-p13.2 NM_002848
15. PTPRQ PTPS31 12q21.31
16. PTPRR PTP-SL, PCPTP,PTPBR7,PC12-PTP1 12q15 NM_002849
17. PTPRS RPTP 19p13.3 NM_002850
18. PTPRT RPTP 20q12-q13 NM_133170
19. PTPRU PTPJ/PTP-U1/PTPRomicron isoforms 1/2/3 1p35.3-p35.1 NM_005704
20. PTPRV OST-PTP 1q32.1
21. PTPRZ RPTP 7q31.3

A. 1.2. NRPTPs (17 Genes)
22. PTPN1 PTP1B 20q13.1-13.2
23. PTPN2 TCPTP, MPTP, PTP-S 18p11.3-11.2

24. PTPN3 PTPH1 9q31 NM_002829
25. PTPN4 PTP-MEG1, TEP 2q14.2 NM_002830
26. PTPN5 STEP 11p15.1 NM_032781
27. PTPN6 SHP1, PTP1C, SH-PTP1,HCP 12p12-13 NM_002831
28. PTPN7 HePTP, LCPTP 1q32.1 NM_002832
29. PTPN9 PTP-MEG2 15q23 NM_002833
30. PTPN11 SHP2, SH-PTP2, Syp,PTP1D, PTP2C, SH-PTP3 12q24.1 NM_002834
31. PTPN12 PTP-PEST, PTP-P19,PTPG1) 7q11.23 NM_002835
32. PTPN13 PTP-BAS, FAP-1, PTP1E,RIP, PTPL1, PTP-BL 4q21.3 NM_006264
33. PTPN14 PTP36, PEZ, PTPD2 1q32.2 NM_005401
34. PTPN18 PTP-HSCF, PTP20, BDP 2q21.2 NM_014369
35. PTPN20 TypPTP 10q11.22
36. PTPN21 PTPD1, PTP2E,PTP-RL10 14q31.3 NM_007039
37. PTPN22 LYP, PEP 1p13.3-p13.1 NM_012411
38. PTPN23 HD-PTP, HDPTP, PTP-TD14, KIAA1471,DKFZP564F0923 3p21.3 NM_015466

A. 2. DSPs or VH1-like (61 Genes)
A. 2. 1. MKPs (11 Genes)
39. DUSP1 MKP-1, 3CH134, PTPN10,erp, CL100/ HVH1 5q34
40. DUSP2 PAC-1 2q11 NM_004418
41. DUSP4 MKP-2, hVH2/TYP1 8p12-p11 NM_001394
42. DUSP5 hVH3/B23 10q25 NM_004419
43. DUSP6 PYST1, MKP-3/rVH6 12q22-q23 NM_001946
44. DUSP7 PYST2, B59, MKP-X 3p21 NM_001947
45. DUSP8 hVH5, M3/6, HB5 11p15.5 NM_004420
46. DUSP9 MKP-4, Pyst3 Xq28 NM_001395
47. DUSP10 MKP-5 1q41 NM_007207
48. DUSP16 MKP-7, MKP-M 12p13 NM_030640
49. MK-STYX MK-STYX 7q11.23

A. 2. 2. Atypical DSPs (19 Genes)
50. DUSP3 VHR, T-DSP11 17q21 NM_004090
51. DUSP11 PIR1 2p13.1 NM_003584
52. DUSP12 HYVH1, GKAP,LMW-DSP4 1q21-q22 NM_007240
53. DUSP13Aa BEDP 10q22.2 NM_016364
54. DUSP13Ba TMDP, TS-DSP6 10q22.2

55. DUSP14 MKP6, MKP-L 17q12 NM_007026
56. DUSP15 VHY, Q9H1R2 20q11.21 NM_080611
57. DUSP18 DUSP20, LMW-DSP20 22q12.2 NM_152511
58. DUSP19 DUSP17, SKRP1, LDP-2,TS-DSP1 2q32.1 NM_080876
59. DUSP21 LMW-DSP21, BJ-HCC-26 tumor antigen Xp11.4-p11.23 NM_022076
60. DUSP22 VHX, MKPX, JSP1, LMW-DSP2, TS-DSP2, JKAP 6p25.3 NM_020185
61. DUSP23 MOSP, similar to RIKEN cDNA 2810004N20 11p11.2 NM_017823
62. DUSP24 MGC1136 8p12 NM_024025
63. DUSP25 VHZ, FLJ20442, LMW-DSP3 1q23.1
64. DUSP26 VHP, “similar to RIKEN cDNA 0710001B24” 2q37.3
65. DUSP27 DUPD1, FMDSP, “similar to cyclophilin” 10q22.3
66. EPM2A Laforin 6q24

67. RNGTT mRNA capping enzyme 6q16 NM_003800
68. STYX STYX 14

A. 2. 3. Slingshots (3 Genes)
69. SSH1 SSH1, slingshot 1 12q24.12 NM_018984
70. SSH2 SSH2, slingshot 2 17q11.2 NM_033389
71. SSH3 SSH3, slingshot 3 11q13.1 NM_018276

A. 2. 4. PRLs (3 Genes)
72. PTP4A1 PRL-1 6q12 NM_003463
73. PTP4A2 PRL-2, OV-1 1p35 NM_080391
74. PTP4A3 PRL-3 8q24.3 NM_007079

A. 2. 5. CDC14s (4 Genes)
75. CDC14A CDC14A 1p21 NM_033312
76. CDC14B CDC14B 9q22.33 NM_033332
77. CDKN3 KAP 14q22 NM_005192
78. PTP9Q22 PTP9Q22 9q22.32 NM_177995

A. 2. 6. PTENs (5 Genes)
79. PTEN PTEN, MMAC1, TEP1 10q23.3 NM_000314
80. TPIP TPIP, TPTE and PTEN homologous 13q12.11
81. TPTE PTEN-like, PTEN2 21p11 NM_013315
82. TNS Tensin 2q35-q36 NM_022648
83. TENC1 C1-TEN, TENC1,KIAA1075 12q13.13 NM_198316

A. 2. 7. Myotubularins (16 Genes)
84. MTM1 myotubularin Xq28 NM_000252
85. MTMR1 MTMR1 Xq28 NM_003828
86. MTMR2 MTMR2 11q22 NM_201278
87. MTMR3 MTMR3, FYVE-DSP1 22q12.2 NM_021090
88. MTMR4 MTMR4, FYVE-DSP2 17q22-q23 NM_004687
89. MTMR5 MTMR1, SBF1 22q13.33 NM_002972
90. MTMR6 MTMR6 13q12 NM_004685
91. MTMR7 MTMR7 8p22
92. MTMR8 MTMR8 Xq11.2 NM_017677
93. MTMR9 MTMR9, LIP-STYX 8p23-p22 NM_015458
94. MTMR10 MTMR10 15q13.1
95. MTMR11 MTMR11CRA 1q12.3
96. MTMR12 MTMR12, 3-PAP 5p13.3 NM_019061
97. MTMR13 MTMR13, SBF2, CMT4B2 11p15.3 NM_030962
98. MTMR14 FLJ22075, hJumpy,hEDTP 3p26 NM_005108

99. MTMR15 KIAA1018 15q13.1

B. Class II Cys-Based PTPs (1 Gene)

100. ACP1 LMPTP, low Mr PTP,LMWPTP, BHPTP 2p25 NM_004300

C. Class III Cys-Based PTPs (3 Genes)

101. CDC25A CDC25A 3p21 NM_001789
102. CDC25B CDC25B 20p13 NM_004358
103. CDC25C CDC25C 5q31 NM_001790

D. Asp-Based PTPs (4 Genes)

104. EYA1 Eya1 8q13.3 NM_172059
105. EYA2 Eya2 20q13.1 NM_172112
106. EYA3 Eya3 1p36 NM_172098
107. EYA4 Eya4 6q23 NM_004100





Reference : Protein Tyrosine Phosphatases in the Human Genome,Andres Alonso, Joanna Sasin, Nunzio Bottini,Ilan Friedberg, Iddo Friedberg,Andrei Osterman, Adam Godzik, Tony Hunter,Jack Dixon, and Tomas Mustelin, Cell(2004), Vol. 117, 699-711.